YfbA, a Yersinia pestis regulator required for colonization and biofilm formation in the gut of cat fleas.

Tam, C., Demke, O., Hermanas, T., Mitchell, A., Hendrickx, A.P., and Schneewind, O.  2014.  YfbA, a… [more]

YfbA, a <em>Yersinia pestis</em> regulator required for colonization and biofilm formation in the gut of cat fleas. YfbA, a <em>Yersinia pestis</em> regulator required for colonization and biofilm formation in the gut of cat fleas.

First publication: A functional and structural analysis of B. abortus RicA

  The Crosson Lab has defined the B. abortus effector protein, RicA, as a carbonic anhydrase-like… [more]

First publication: A functional and structural analysis of <em>B. abortus</em> RicA First publication: A functional and structural analysis of <em>B. abortus</em> RicA

The Chicago Center for Functional Annotation (CCFA) is defining gene function on multiple scales, using a multi-disciplinary set of cellular, genetic, molecular, and biochemical approaches. The primary goal of the CCFA is to define the biochemical and cellular functions of uncharacterized genes in the NIAID priority pathogens, Yersinia pestis and Brucella abortus.

Progress of biophysical characterization

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NIAID Functional Genomics Program

The NIAID Functional Genomics Program will generate experimental data that define the biochemical function(s) of hypothetical genes, unknown open reading frames, and noncoding RNAs in infectious disease pathogens. Obtaining a more comprehensive understanding of uncharacterized genes in infectious disease pathogens will lead to improved genomic annotation and allow for the development of potential new targets for medical diagnostics, therapeutics and vaccines. This program will distribute data, software, and reagents generated from the research projects to the broader scientific community. These research activities are carried out at four sites:
1) Harvard School of Public Health
2) University of Chicago
3) University of North Carolina-Chapel Hill
4) University of Washington