Host infection by microbial pathogens cues global changes in microbial and host cell biology that facilitate microbial replication and disease. The complete maps of thousands of bacterial and viral genomes have recently been defined; however, the rate at which physiological…
The Brucella abortus general stress response (GSR) system regulates activity of the alternative sigma factor, σ(E1), which controls transcription of approximately 100 genes and is required for persistence in a BALB/c mouse chronic infection model. We evaluated the host response…
The general stress response (GSR) system of the intracellular pathogen Brucella abortus controls transcription of approximately 100 genes in response to a range of stress cues. The core genetic regulatory components of the GSR are required for B. abortus survival…
We have functionally and structurally defined an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival of the global zoonotic pathogen Brucella abortus. Our study delineates phosphoryl transfer through this molecular pathway, which initiates…
The 2016 NIAID Functional Genomics program meeting will be hosted by Harvard University on May 2-4, 2016 in Boston, MA.
Tam, C., Demke, O., Hermanas, T., Mitchell, A., Hendrickx, A.P., and Schneewind, O. 2014. YfbA, a Yersinia pestis regulator required for colonization and biofilm formation in the gut of cat fleas. J. Bacteriol. doi: 10.1128/JB.01187-13.
The Crosson Lab has defined the B. abortus effector protein, RicA, as a carbonic anhydrase-like zinc metalloprotein. This work was published in Biochemistry.