Blog Archives

Next-Generation High-Throughput Functional Annotation of Microbial Genomes

Host infection by microbial pathogens cues global changes in microbial and host cell biology that facilitate microbial replication and disease. The complete maps of thousands of bacterial and viral genomes have recently been defined; however, the rate at which physiological

Posted in Publications

A dual-targeting approach to inhibit Brucella abortus replication in human cells.

Brucella abortus is an intracellular bacterial pathogen and an etiological agent of the zoonotic disease known as brucellosis. Brucellosis can be challenging to treat with conventional antibiotic therapies and, in some cases, may develop into a debilitating and life-threatening chronic

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WrpA is an atypical flavodoxin-family protein under regulatory control of the Brucella abortus general stress response system.

The general stress response (GSR) system of the intracellular pathogen Brucella abortus controls transcription of approximately 100 genes in response to a range of stress cues. The core genetic regulatory components of the GSR are required for B. abortus survival

Posted in Publications

Structural asymmetry in a conserved signaling system that regulates division, replication and virulence of an intracellular pathogen.

We have functionally and structurally defined an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival of the global zoonotic pathogen Brucella abortus. Our study delineates phosphoryl transfer through this molecular pathway, which initiates

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The Brucella abortus virulence regulator, LovhK, is a sensor kinase in the general stress response signaling pathway

Summary In the intracellular pathogen Brucella abortus, the general stress response (GSR) signaling system determines survival under acute stress conditions in vitro, and is required for long-term residence in a mammalian host. To date, the identity of the Brucella sensor

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YfbA, a Yersinia pestis regulator required for colonization and biofilm formation in the gut of cat fleas.

Tam, C., Demke, O., Hermanas, T., Mitchell, A., Hendrickx, A.P., and Schneewind, O.  2014.  YfbA, a Yersinia pestis regulator required for colonization and biofilm formation in the gut of cat fleas.  J. Bacteriol.  doi: 10.1128/JB.01187-13.

Posted in Publications