Gene network analysis identifies a central post-transcriptional regulator of cellular stress survival

The Crosson lab described a network-based approach to interrogate publicly available transcription data to predict genes that serve major functional roles in Caulobacter crescentus stress survival. This approach identified GsrN, a conserved small RNA whose expression is both necessary and sufficient to protect cells from hydrogen peroxide, convening a post-transcriptional layer of gene expression that serves a central functional role in stress physiology.


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