Yersinia pestis

Viewed globally, plague epidemics in human populations occur every year, however pandemics with devastating consequences are often separated by long time intervals.  Current epidemiological studies record about 4,000 human plague cases annually world-wide; morbidity rates oscillate and slowly increase towards the onset of a new pandemic.  Due to its fulminant spread and very high mortality, plague has killed more people worldwide than any other infectious disease.

The CCFA research project on Yersinia pestis is led by Dr. Olaf Schneewind of the University of Chicago, and is defining the function of numerous uncharacterized ORFs and small RNAs involved in plague pathogenesis and replication within the flea vector.

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